613 research outputs found
Design of experiments for non-manufacturing processes : benefits, challenges and some examples
Design of Experiments (DoE) is a powerful technique for process optimization that has been widely deployed in almost all types of manufacturing processes and is used extensively in product and process design and development. There have not been as many efforts to apply powerful quality improvement techniques such as DoE to improve non-manufacturing processes. Factor levels often involve changing the way people work and so have to be handled carefully. It is even more important to get everyone working as a team. This paper explores the benefits and challenges in the application of DoE in non-manufacturing contexts. The viewpoints regarding the benefits and challenges of DoE in the non-manufacturing arena are gathered from a number of leading academics and practitioners in the field. The paper also makes an attempt to demystify the fact that DoE is not just applicable to manufacturing industries; rather it is equally applicable to non-manufacturing processes within manufacturing companies. The last part of the paper illustrates some case examples showing the power of the technique in non-manufacturing environments
Macroscopic resonant tunneling of magnetic flux
We have developed a quantitative theory of resonant tunneling of magnetic
flux between discrete macroscopically distinct quantum states in SQUID systems.
The theory is based on the standard density-matrix approach. Its new elements
include the discussion of the two different relaxation mechanisms that exist
for the double-well potential, and description of the ``photon-assisted''
tunneling driven by external rf radiation. It is shown that in the case of
coherent flux dynamics, rf radiation should lead to splitting of the peaks of
resonant flux tunneling, indicating that the resonant tunneling is a convenient
tool for studying macroscopic quantum coherence of flux.Comment: 11 pages, 8 figure
Biomarkers and outcome after tamoxifen treatment in node-positive breast cancers from elderly women
The predictive role of tumour proliferative rate and expression of p53, bcl-2 and bax proteins, alone and in association with tumour size, nodal involvement and oestrogen receptors (ER), was analysed on 145 elderly patients (≥70 years of age) with histologically assessed node-positive breast cancers treated with radical or conservative surgery plus radiotherapy followed by adjuvant tamoxifen for at least 1 year. The 7-year probability of relapse was significantly higher for patients with tumours rapidly proliferating (hazard ratio (HR) = 2.0, P = 0.01), overexpressing p53 (HR = 4.4, P = 0.0001), weakly or not exhibiting bcl-2 (HR = 1.9, P = 0.02), without ERs (HR = 3.4, P = 0.0001) or with ≥ 4 positive lymph nodes (HR = 2.3, P = 0.003) than for patients with tumours expressing the opposite patho-biological profile. Conversely, tumour size and bax expression failed to influence relapse-free survival. Adjustment for the duration of tamoxifen treatment did not change these findings. Oestrogen receptors, cell proliferation, p53 accumulation and bcl-2 expression were also predictive for overall survival. Within ER-positive tumours, cell proliferation, p53 accumulation, bcl-2 expression and lymph node involvement provided significant and independent information for relapse and, in association, identified subgroups of patients with relapse probabilities of 20% (low-risk group, exhibiting only one unfavourable factor) to 90% (high-risk group, exhibiting three unfavourable factors). Such data could represent the initial framework for a biologically tailored therapy even for elderly patients and highlight the importance of a patho-biological characterization of their breast cancers. © 2000 Cancer Research Campaig
Pinch Resonances in a Radio Frequency Driven SQUID Ring-Resonator System
In this paper we present experimental data on the frequency domain response
of a SQUID ring (a Josephson weak link enclosed by a thick superconducting
ring) coupled to a radio frequency (rf) tank circuit resonator. We show that
with the ring weakly hysteretic the resonance lineshape of this coupled system
can display opposed fold bifurcations that appear to touch (pinch off). We
demonstrate that for appropriate circuit parameters these pinch off lineshapes
exist as solutions of the non-linear equations of motion for the system.Comment: 9 pages, 8 figures, Uploaded as implementing a policy of arXiving old
paper
Adiabatic evolution of a coupled-qubit Hamiltonian
We present a general method for studying coupled qubits driven by
adiabatically changing external parameters. Extended calculations are provided
for a two-bit Hamiltonian whose eigenstates can be used as logical states for a
quantum CNOT gate. From a numerical analysis of the stationary Schroedinger
equation we find a set of parameters suitable for representing CNOT, while from
a time-dependent study the conditions for adiabatic evolution are determined.
Specializing to a concrete physical system involving SQUIDs, we determine
reasonable parameters for experimental purposes. The dissipation for SQUIDs is
discussed by fitting experimental data. The low dissipation obtained supports
the idea that adiabatic operations could be performed on a time scale shorter
than the decoherence time.Comment: 10 pages, 4 figures, to be pub.in Phys Rev
A Fully Quantum Mechanical Model of a SQUID Ring Coupled to an Electromagnetic Field
A quantum system comprising of a monochromatic electromagnetic field coupled
to a SQUID ring with sinusoidal non-linearity, is studied. A magnetostatic flux
is also threading the SQUID ring, and is used to control the
coupling between the two systems. It is shown that for special values of
the system is strongly coupled. The time evolution of the system is
studied. It is shown that exchange of energy takes place between the two modes
and that the system becomes entangled. A second quasi-classical model that
treats the electromagnetic field classically is also studied. A comparison
between the fully quantum mechanical model with the electromagnetic field
initially in a coherent state and the quasi-classical model, is made.Comment: 7 pages, 9 figures. Uploaded as implementing a policy of arXiving old
paper
Angles from Decays with Charm
Proceedings of the CKM 2005 Workshop (WG5), UC San Diego, 15-18 March 2005.Comment: 62 pages, 55 figures. Proceedings of the CKM 2005 Workshop (WG5), UC
San Diego, 15-18 March 200
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